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Aging the Bone: The
Degenerative Effects of Skeletal Fluorosis
Now let's look at the bone. Unlike the ameloblasts,
and odontoblasts of teeth whose regenerative activity stops after tooth
development, osteoblasts continue to actively lay down collagen, and new bone
formation continues to take place.
If a tooth breaks or fractures, you're out of luck. The damage cannot be
repaired. However, if a bone breaks or fractures, osteoblasts lay down collagen
to produce a framework for new bone formation to repair the damage.
Bone also has the ability to rejuvenate itself. As older bone is removed by
bone scavenger cells called osteoclasts, osteoblasts lay down collagen to
produce a framework for new bone formation to renew the skeletal structure.
Thus, damage to collagen production in bone can interfere with the normal
processes of bone rejuvenation and repair throughout life.
Cartilage
The balls and sockets of bones are lined with a
smooth, tough elastic substance called cartilage. Maintaining the integrity of
cartilage depends largely upon the ability of cells called chondroblasts to lay
down noncalcified collagen which is the major structural component of
cartilage.
The Effect of Fluoride on Bone and Cartilage
Fluoride has been shown to interfere with collagen formation in osteoblasts and
chondroblasts. If, as pointed out, increased production of imperfect collagen
or collagen-like protein results in mineralization of tissues which should not
be mineralized, and vice versa, one would expect a calcification of ligaments,
cartilage, and tendons as well as the formation of poorly and overly
mineralized bone. This is exactly what happens after exposure to fluoride.
In discussing their examination of tissues from patients exposed to fluoride,
Drs. A. Singh and S.S. Jolly, world-renowned experts on the clinical effects of
fluoride on bone, point out that
- The most noticeable changes are detected in the spine with calcification of
various spinal ligaments, resulting in pronounced bony outgrowths. The other
bones show numerous spiky outgrowths especially in tendons (collagen-rich
fibrous tissue which attach muscles to bone) and ligaments (collagen rich
fibrous tissue which holds bones together). Under careful inspection, the bony
outgrowths are found to consist of coarse, woven fibers which are largely
uncalcified.
- Irregular bone is also laid down in joint sockets
and interosseous membranes (membranes between bones in arms and legs).
- In more advanced cases of fluoride exposure, bones become held together by masses of new bone laid down in the joint socket, ligaments and tendons. This results in the locking up of joints and permanent inability of victims to move or flex their joints. Vertebrae become fused at many places. This results in the characteristic 'hunch back' symptom of skeletal fluorosis.
- There is a low degree of remineralization of the bone itself, which is partly due to a wide seam of uncalcified osteoid (collagen).
In 1973, Dr. Jolly and co-workers presented radiological evidence of skeletal fluorosis which results in these bone deformities in parts of India where the drinking water contained as little as 0.7 parts per million fluoride, with the occurrence and severity increasing with increasing levels of fluoride in the drinking water.
RADIOLOGICAL EVIDENCE OF SKELETAL FLUOROSIS IN MALES 21 YEARS OF AGE AND OLDER |
||
Village |
Water Fluoride (ppm) |
Percentage |
Mandi Baretta | ||
Kooriwara | ||
Gurnay Kalan | ||
Ganza Dhanaula | ||
Bajakhana | ||
Rajia | ||
Village Baretta | ||
Rorki | ||
Saideke | ||
Khara |
In 1985, Dr. I. Arnala and co-workers of Kuopio University in
Finland reported that: 'The upper limit for fluoride concentration in
drinking water that does not increase the amount of unmineralized bone is
roughly 1.5 parts per million. We should however, recognize that it is
difficult to give a strict value for a safe concentration in drinking water
because individual susceptibility to fluoride varies.'
In addition to fluoride-induced bone irregularities, one could expect that the
fluoride-induced irregularities of the joint cartilage (which is normally
smooth) would result in the irritation and inflammation commonly referred to as
arthritis. One could also expect fluoride to cause an increase in the incidence
of fractures and a decrease in the body's ability to heal bone breaks and bone
fractures.
Clinical observations show that this is exactly what happens.
Arthritic Changes
Drs. Singh and Jolly point out that early symptoms of
fluoride-induced damage to bones and cartilage start with 'vague pains
noted most frequently in the small joints of the spine. These cases are
frequent in the endemic [local] areas and may be misdiagnosed as
rheumatoid or osteoarthritis.
'In later stages, there is an obvious stiffness of the spine with
limitation of movements, and still later, the development of kyphosis [hunch
back].
'There is difficulty in walking, due partly to stiffness and limitation of
the movements of various joints.
'Some patients complain of dyspnea, [difficulty in breathing] on
exertion because of the rigidity of the thoracic cage.'
Dr. Jolly and co-workers reported these symptoms in parts of
In the United States, Dr. George Waldbott also diagnosed some of the early
symptoms listed above, including arthritis and joint pains, as being due to the
consumption of water fluoridated at 1 part per million. He was able to bring
about a reversal in these symptoms by eliminating fluoridated water from the
patients'diets. However, if left unattended, the degeneration leads to the
advanced stages of arthritis and 'old age.'
Similar arthritic symptoms have been reported among people exposed to air-borne
fluoride in
Dr.Waldbott noted the possibility of the age-accelerating effects of fluoride
with respect to arthritis and stated:
'Among the elderly, arthritis of the spine is an especially common ailment
that is customarily attributed to 'aging.' Since fluoride retention in bones
increases as a person grows older, how can we disregard the possibility that
this 'old age' disease might be linked with fluoride intake? For example
[others have] described in detail X-ray changes encountered in skeletal
fluorosis in North Africa, that are in every respect identical to those present
in the arthritic spine of the elderly.'
Breaks and Fractures
In 1978, Dr. J.A. Albright and co-workers from
In 1983, Dr. B. Uslu from Anadelu University School of Medicine in
In 1978, the Journal of the American Medical Association published
an editorial pointing out that 'in several short-term studies, fluoride
has been administered for treatment of involutional osteoporosis, alone or with
supplemental calcium, vitamin D or both. No studies have demonstrated
alleviation of fracture[s]. However, studies in humans have shown an
increased incidence of fractures. When high doses of fluorides have been
given to animals receiving a diet that was otherwise unchanged, most studies
have shown no change or a decrease in the strength of the bone.' They
also pointed out that administration of fluoride resulted in nonmineralized
seams in bones, resulting in the disease called osteomalacia. These nonmineralized
seams imply that breaks and fractures in the patients' bones would tend to heal
more slowly.
It is ironic that anyone would ever think of treating osteoporosis (a disease
in which the bones lose calcium) with fluoride, a substance which leads to
decalcification of bone. In 1977, Dr. Jennifer Jowsey, one of the originators
of fluoride therapy for osteoporosis, admitted that fluoride was leading to a
greater degree of osteoporosis (demineralization) in some bones while leading
to osteosclerosis (overmineralization) in others. In other words, fluoride
treatment of osteoporosis 'robs Peter to pay Paul' and leads to a
general weakening of the bones.
In 1980, Dr. J.C. Robin and co-workers from the Roswell Park Memorial Institute
confirmed the foolishness of using fluoride for the treatment of osteoporosis
by publishing their results in the Journal of Medicine. According
to the authors, 'fluoride had no preventive effect. In some experiments
there was even a deleterious effect of fluoride.' They found fluoride
accelerated the process of osteoporosis leading to a loss of calcium from the
bone.
Claims that the amount of fluoride found in fluoridated water would help
prevent osteoporosis have been studied epidemiologically. Researchers from the
U.S. National Center for Health Statistics claimed to find no preventive
effect, while researchers from the National Board of Health in
In 1973, a report from the National Institute of Arthritis and Metabolic
Diseases found 50 to 100% increases in the incidence of a disease called
osteitis fibrosa among patients whose artificial kidney machines were run on
fluoridated water. Osteitis fibrosa is a disease characterized by fibrous
degeneration of the bone; it results in bone deformities and sometimes in
fracture...
Hardening of the Arteries
In a number of areas where people consume water containing 3
parts per million fluoride or more, calcification of
the arteries has been clinically correlated with the fluoride-induced bone
disorders described in Chapter 6. The indication again is that fibroblasts in
the arterial cell walls are producing larger amounts of an imperfect collagen
or collagen-like protein, resulting in hardening of the arteries or
arteriosclerosis, the leading cause of death in the
During aging, hardening of the arteries is
probably due to disruption of collagen production, according to Dr. John Negalesko,
director of the first year medical program at the
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